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. 2020 Aug 17;15(8):e0231234. doi: 10.1371/journal.pone.0231234

Fig 6. Effect of treatment of ZSF1 obese rats with Fc-GDF15 on systemic metabolic biomarkers.

Fig 6

Treatment of ZSF1 rat with Fc-GDF15 resulted in decreased body weight (A) and food intake (B), decrease in blood triglyceride (C) and glucose levels (D), and trend in decrease of blood cholesterol (E). Blood insulin increased over time with GDF15 treatment (F). Twelve weeks of Fc-GDF15 treatment resulted in increased blood adiponectin (G) and had no effect on endogenous levels of rat GDF15 (H). When the effect in vehicle-treated and Fc-GDF15–treated obese ZSF1 rats was studied longitudinally (0–12 weeks), a two-way ANOVA with Sidak’s multiple comparison test was performed for metabolic parameters, body weight, and food intake (A-F). Unpaired Student’s t test was performed to evaluate the statistical significance between the groups at the end of a study (G, H). Stars (*) indicate significance (* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001). n = 15 for the vehicle-treated obese ZSF1 group and n = 12 for the Fc-GDF15–treated obese ZSF1 group.