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. 2020 Aug 17;15(8):e0231234. doi: 10.1371/journal.pone.0231234

Fig 7. Effect of Fc-GDF15 treatment of ZSF1 obese rats on systemic CVD biomarkers.

Fig 7

Obese ZSF1 rats treated with Fc-GDF15 for 12 weeks exhibit decrease in systemic levels of cardiovascular disease (CVD)–related biomarkers vWF (A), Myl3 (B), osteopontin (C), sE-selectin (D), sICAM (E), VEGF (F), and TIMP-1 (G) at the end of the study. Stars (*) indicate significance (* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001) by unpaired two-tailed t test. n = 15 for the vehicle-treated group and n = 12 for the Fc-GDF15–treated group.