Skip to main content
. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Nature. 2020 Apr 1;580(7803):396–401. doi: 10.1038/s41586-020-2164-5

Extended Data Figure 6. Unsupervised multi-omics factor integration analysis of MBSHH.

Extended Data Figure 6.

a. Overview of input samples and data types.

b. Latent factors variance summary across data types.

c. Somatic/germline gene alterations contributing to latent factor 1 (LF1).

d. Association between germline ELP1 mutation status and LF1 score (n=16 patients). P value was calculated using a two-sided Mann-Whitney U-test. Boxes show median, first and third quartile, and whiskers extend to 1.5× the interquartile range.

e. Functional enrichment of LF1-ranked proteins and mRNAs.