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. 2020 Aug 5;13:7793–7805. doi: 10.2147/OTT.S249494

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© 2020 Yu et al.

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Circ_0005576 knockdown inhibited tumor growth and induced apoptosis in vivo. (A) After 28 days of inoculation, knockdown of circ_0005576 significantly reduced xenograft tumor volume. (B) Picture of xenograft tumor tissues after 28 days of inoculation. (C) Knockdown of circ_0005576 significantly reduced xenograft tumor weight after 28 days of inoculation. (D) Immunohistochemical results revealed that, knockdown of circ_0005576 significantly reduced CDK8 and Ki67 expression in xenograft tumor tissues. (E) Tunel assay indicated that circ_0005576 knockdown obviously increased cell apoptosis in xenograft tumor tissues. **P < 0.01.

Abbreviation: NC, negative control.