Fig. 1.

SOX10 binds to promoter elements in Schwann cells in vivo. a Tn5Prime-defined transcription start sites (TSSs) in sciatic nerve mapping within 1 kilobase of SOX10 and/or H3K4me3 ChIP-Seq peaks. b Expression levels of TSS classes (as in panel A). X-axis: log10 transformed average expression level (reads per million, RPM). Y-axis: the cumulative fraction of TSSs. Asterisk indicates p < 0.00001. c Aggregate SOX10 ChIP-Seq data in the 2-kilobase region surrounding TSS classes (as in panel A). X-axis: genomic distance from the TSS (base pairs, bp). Y-axis: average SOX10 ChIP-Seq signal (RPM, reads per million). Asterisk indicates p < 0.01