Table 2.
Top 30 enriched gene ontology terms for transcription start sites that are upregulated upon primary Schwann cell differentiation, ranked by fold enrichment. Beneath each term is a list of the genes that contributed to the term’s enrichment
| Gene Ontology Term | Fold Enrichment | FDR-Corrected P-Value |
|---|---|---|
| Isopentenyl diphosphate biosynthetic process (GO:0009240) | 36.73 | 1.56E-02 |
| Idi1, Pmvk, Mvk | ||
| Isopentenyl diphosphate metabolic process (GO:0046490) | 36.73 | 1.55E-02 |
| Idi1, Pmvk, Mvk | ||
| Ribosomal small subunit export from nucleus (GO:0000056) | 26.23 | 2.99E-02 |
| Ran, Rps15, Npm1 | ||
| Cholesterol biosynthetic process (GO:0006695) | 17.49 | 1.55E-08 |
| Insig1, Hds17b7, Hmgcr, Msmo1, Hmgcs1, Idi1, Pmvk, Tm7sf2, Fdft1, Mvk, Acly, Sc5d | ||
| Secondary alcohol biosynthetic process (GO:1902653) | 17.08 | 1.87E-08 |
| Insig1, Hsd17b7, Hmgcr, Msmo1, Hmgcs1, Idi1, Pmvk, Tm7sf2, Fdft1, Mvk, Acly, Sc5d | ||
| SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 17.04 | 2.45E-19 |
| Rpl18a, Rps15, Rpl9, Rps10, Rpl37a, Rpl29, Rps3a, Rpl13, Rpl23a, Rpl17, Rpl11, Rpl23, Rps5, Rps14, Rps18, Uba52, Rpl35, Rps25, Rpl26, Rpl18, Rpl3, Rps27a, Rps13, Rpl7, Rps26, Rplp0, Rpl5 | ||
| Coenzyme A metabolic process (GO:0015936) | 16.32 | 1.52E-02 |
| Hmgcr, Mccc2, Coasy, Acly | ||
| Cotranslational protein targeting to membrane (GO:0006613) | 16.2 | 5.64E-19 |
| Rpl18a, Rps15, Rpl9, Rps10, Rpl37a, Rpl29, Rps3a, Rpl13, Rpl23a, Rpl17, Rpl11, Rpl23, Rps5, Rps14, Rps18, Uba52, Rpl35, Rps25, Rpl26, Rpl18, Rpl3, Rps27a, Rps13, Rpl7, Rps26, Rplp0, Rpl5 | ||
| Ribosomal small subunit assembly (GO:0000028) | 15.3 | 3.80E-03 |
| Rps15, Rps10, Rps5, Rps14, Rps27l | ||
| Sterol biosynthetic process (GO:0016126) | 15.3 | 4.86E-08 |
| Insig1, Hsd17b7, Hmgcr, Msmo1, Hmgcs1, Idi1, Pmvk, Tm7sf2, Fdft1, Mvk, Acly, Sc5d | ||
| Protein targeting to ER (GO:0045047) | 15.02 | 2.04E-18 |
| Rpl18a, Rps15, Rpl9, Rps10, Rpl37a, Rpl29, Rps3a, Rpl13, Rpl23a, Rpl17, Rpl11, Rpl23, Rps5, Rps14, Rps18, Uba52, Rpl35, Rps25, Rpl26, Rpl18, Rpl3, Rps27a, Rps13, Rpl7, Rps26, Rplp0, Rpl5 | ||
| Viral transcription (GO:0019083) | 14.9 | 5.06E-19 |
| Rpl18a, Rps15, Rpl9, Rps10, Rpl37a, Rpl29, Rps3a, Rpl13, Rpl23a, Rpl17, Rpl11, Rpl23, Rps5, Rps14, Rps18, Uba52, Rpl35, Rps25, Rpl26, Rpl18, Rpl3, Rps27a, Rps13, Rpl7, Rps26, Rplp0, Seh1l, Rpl5 | ||
| Establishment of protein localization to endoplasmic reticulum (GO:0072599) | 14.5 | 3.04E-18 |
| Rpl18a, Rps15, Rpl9, Rps10, Rpl37a, Rpl29, Rps3a, Rpl13, Rpl23a, Rpl17, Rpl11, Rpl23, Rps5, Rps14, Rps18, Uba52, Rpl35, Rps25, Rpl26, Rpl18, Rpl3, Rps27a, Rps13, Rpl7, Rps26, Rplp0, Rpl5 | ||
| Regulation of cholesterol biosynthetic process (GO:0045540) | 14.24 | 2.22E-06 |
| Ran, Hmgcr, Hmgcs1, Idi1, Nfya, Pmvk, Tm7sf2, Fdft1, Mvk, Sc5d | ||
| Regulation of sterol biosynthetic process (GO:0106118) | 14.24 | 2.19E-06 |
| Ran, Hmgcr, Hmgcs1, Idi1, Nfya, Pmvk, Tm7sf2, Fdft1, Mvk, Sc5d | ||
| Viral gene expression (GO:0019080) | 14.24 | 2.34E-19 |
| Rpl18a, Rps15, Rpl9, Pcbp2, Rps10, Rpl37a, Rpl29, Rps3a, Rpl13, Rpl23a, Rpl17, Rpl11, Rpl23, Rps5, Rps14, Rps18, Uba52, Rpl35, Rps25, Rpl26, Rpl18, E1f3f, Rpl3, Rps27a, Rps13, Rpl7, Rps26, Rplp0, Seh1l, Rpl5 | ||
| Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 13.77 | 7.89E-18 |
| Rpl18a, Rps15, Rpl9, Rps10, Rpl37a, Rpl29, Rps3a, Rpl13, Rpl23a, Rpl17, Rpl11, Rpl23, Rps5, Rps14, Rps18, Uba52, Rpl35, Rps25, Rpl26, Rpl18, Rpl3, Rps27a, Rps13, Rpl7, Rps26, Rplp0, Rpl5 | ||
| Isoprenoid biosynthetic process (GO:0008299) | 13.12 | 1.47E-03 |
| Hmgcr, Hmgcs1, Idi1, Pmvk, Mvk | ||
| Translational initiation (GO:0006413) | 13 | 2.20E-19 |
| Eif2b4, Rpl18a, Rps15, Rpl9, Rps10, Rpl37a, Rpl29, Rps3a, Rpl13, Eif4b, Rpl23a, Rpl17, Rpl11, Rpl23, Rps5, Rps14, Rps18, Uba52, Rpl35, Rps25, Rpl26, Rpl18, Eif3f, Rpl3, Rps27a, Eif1b, Rps13, Rpl7, Rps26, Rplp0 | ||
| Protein localization to endoplasmic reticulum (GO:0070972) | 12.96 | 1.83E-18 |
| Insig1, Rpl18a, Rps15, Rpl9, Rps10, Rpl37a, Rpl29, Rps3a, Rpl13, Rpl23a, Rpl17, Rpl11, Rpl23, Rps5, Bcap29, Rps14, Rps18, Uba52, Rpl35, Rps25, Rpl26, Rpl18, Rpl3, Rps27a, Rps13, Rpl7, Rps26, Rplp0, Rpl5 | ||
| Myelin assembly (GO:0032288) | 12.89 | 2.98E-02 |
| Ncmap, Cd9, Mtmr2, Pmp22 | ||
| Nucleotide-excision repair, DNA duplex unwinding (GO:0000717) | 11.13 | 4.41E-02 |
| Uba52, Rps27a, Gtf2h1, Ddb1 | ||
| Regulation of cholesterol metabolic process (GO:0090181) | 10.93 | 1.50E-05 |
| Ran, Hmgcr, Hmgcs1, Idi1, Nfya, Pmvk, Tm7sf2, Fdft1, Mvk, Sc5d | ||
| Protein targeting to membrane (GO:0006612) | 10.65 | 4.14E-16 |
| Rpl18a, Rps15, Rpl9, Rps10, Rpl37a, Rpl29, Rps3a, Rpl13, Rab8b, Rpl23a, Pmp22, Rpl17, Rpl11, Aldh3a2, Rpl23, Rps5, Rps14, Rps18, Uba52, Rpl35, Rps25, Rpl26, Rpl18, Rpl3, Rps27a, Rps13, Rpl7, Rps26, Rplp0, Rpl5 | ||
| Glucose 6-phosphate metabolic process (GO:0051156) | 10.65 | 4.94E-02 |
| G6pc3, Taldo1, Pgls, Gpi | ||
| Myelination (GO:0042552) | 10.59 | 4.51E-10 |
| Eif2b4, Mbp, Lpar1, Bcas1, Serinc5, Lgi4, Ncmap, Pllp, Egr2, Mpz, Id4, Acer3, Cd9, Mag, Dhh, Jam3, Mtmr2, Pmp22, Mal | ||
| Ensheathment of neurons (GO:0007272) | 10.39 | 5.84E-10 |
| Eif2b4, Mbp, Lpar1, Bcas1, Serinc5, Lgi4, Ncmap, Pllp, Egr2, Mpz, Id4, Acer3, Cd9, Mag, Dhh, Jam3, Mtmr2, Pmp22, Mal | ||
| Axon ensheathment (GO:0008366) | 10.39 | 5.70E-10 |
| Eif2b4, Mbp, Lpar1, Bcas1, Serinc5, Lgi4, Ncmap, Pllp, Egr2, Mpz, Id4, Acer3, Cd9, Mag, Dhh, Jam3, Mtmr2, Pmp22, Mal | ||
| Ribosome assembly (GO:0042255) | 10.05 | 8.16E-06 |
| Rps15, Rps10, Rpl23a, Rpl11, Rps5, Rps14, Rps27l, Npm1, Rpl3, Rplp0, Rpl5 | ||
| Cytoplasmic translation (GO:0002181) | 9.62 | 1.17E-05 |
| Rpl18a, Rpl9, Rpl29, Eif4b, Rpl17, Rpl11, Rpl26, Rpl18, Eif3f, Rps26, Rplp0 | ||