Table 3.
Top 30 enriched gene ontology terms for transcription start sites that are downregulated upon primary Schwann cell differentiation, ranked by fold enrichment. Beneath each term is a list of the genes that contributed to the term’s enrichment
| Gene Ontology Term | Fold Enrichment | FDR-Corrected P-Value |
|---|---|---|
| Vesicle transport along actin filament (GO:0030050) | 33.96 | 2.44E-02 |
| Wasl, Fnbp1l, Actn4 | ||
| Regulation of protein folding (GO:1903332) | 22.64 | 8.45E-03 |
| Bag5, Dnajb2, Sgtb, St13 | ||
| Activation of MAPKKK activity (GO:0000185) | 20.58 | 1.08E-02 |
| Traf7, Gadd45b, Gadd45a, Gadd45g | ||
| Response to laminar fluid shear stress (GO:0034616) | 18.86 | 2.87E-03 |
| Klf2, Xbp1, Nfe2l2, Ets1, Adam9 | ||
| Establishment of protein localization to mitochondrial membrane (GO:0090151) | 13.32 | 3.33E-02 |
| Hsp90aa1, Tomm22, Timm10 | ||
| Membrane protein intracellular domain proteolysis (GO:0031293) | 12.58 | 3.83E-02 |
| Aph1a, Traf6, Aph1b, Ngfr | ||
| Membrane protein proteolysis (GO:0033619) | 10.71 | 1.80E-03 |
| Aph1a, Traf6, Aph1b, Adam19, Ngfr, Ctsh, Adam9 | ||
| Response to fluid shear stress (GO:0034405) | 9.99 | 7.03E-03 |
| Klf2, Xbp1, Cited2, Nfe2l2, Ets1, Adam9 | ||
| Multivesicular body sorting pathway (GO:0071985) | 8.84 | 3.32E-02 |
| Rubcn, Vps25, Vps28, Vps4b, Chmp3 | ||
| Positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:0036003) | 8.84 | 3.30E-02 |
| Klf2, Xbp1, Nfe2l2, Atf4, Ddit3 | ||
| Interleukin-12-mediated signaling pathway (GO:0035722) | 8.61 | 4.59E-03 |
| P4hb, Capza1, Hnrnpdl, Cfl1, Rala, Rplp0, Pak2 | ||
| Cortical actin cytoskeleton organization (GO:0030866) | 8.49 | 1.36E-02 |
| Calr, Cavin3, Arf6, Tln1, Ehd2 | ||
| Cellular response to interleukin-12 (GO:0071349) | 8.25 | 5.46E-03 |
| P4hb, Capza1, Hnrnpdl, Cfl1, Rala, Rplp0, Pak2 | ||
| Response to interleukin-12 (GO:0070671) | 8.08 | 6.06E-03 |
| P4hb, Capza1, Hnrnpdl, Cfl1, Rala, Rplp0, Pak2 | ||
| ER-nucleus signaling pathway (GO:0006984) | 7.86 | 4.74E-02 |
| Calr, Xbp1, Nfe2l2, Atf4, Ddit3 | ||
| Cortical cytoskeleton organization (GO:0030865) | 7.55 | 2.25E-02 |
| Calr, Cavin3, Arf6, Rhoc, Tln1, Ehd2 | ||
| Response to epidermal growth factor (GO:0070849) | 6.93 | 3.03E-02 |
| Tpr, Col1a1, Gstp1, Zfp36, Snai2, Mars | ||
| Response to unfolded protein (GO:0006986) | 6.41 | 2.32E-06 |
| Hspb2, Hsp90aa1, Dnajb2, Calr, Serpinh1, Derl2, Dnajb11, Xbp1, Arfgap1, Fkbp14, Nfe2l2, Atf4, Syvn1, Tmem129, Ddit3, Tln1, Bag3, Optn | ||
| Endoplasmic reticulum unfolded protein response (GO:0030968) | 6.23 | 8.34E-04 |
| Calr, Derl2, Dnajb11, Xbp1, Arfgap1, Fkbp14, Nfe2l2, Atf4, Syvn1, Ddit3, Tln1 | ||
| Negative regulation of intracellular transport (GO:0032387) | 6.19 | 2.13E-02 |
| Cryab, Derl2, Tpr, Itgb1bp1, Map 1b, Bag3, Snx12 | ||
| IRE1-mediated unfolded protein response (GO:0036498) | 6.17 | 4.57E-02 |
| Dnajb11, Xbp1, Arfgap1, Fkbp14, Syvn1, Tln1 | ||
| Cellular response to unfolded protein (GO:0034620) | 6.03 | 2.09E-04 |
| Calr, Derl2, Dnajb11, Xbp1, Arfgap1, Fkbp14, Nfe2l2, Atf4, Syvn1, Ddit3, Tln1, Bag3, Optn | ||
| Intracellular steroid hormone receptor signaling pathway (GO:0030518) | 5.74 | 2.91E-02 |
| Tada3, Calr, Ddx5, Ywhah, Ube3a, Nedd4, Plpp1 | ||
| Response to topologically incorrect protein (GO:0035966) | 5.6 | 9.46E-06 |
| Hspb2, Hsp90aa1, Dnajb2, Calr, Serpinh1, Derl2, Dnajb11, Xbp1, Arfgap1, Fkbp14, Nfe2l2, Atf4, Syvn1, Tmem129, Ddit3, Tln1, Bag3, Optn | ||
| Positive regulation of axonogenesis (GO:0050772) | 5.33 | 2.01E-02 |
| Chd2, Map 2k1, Arhgdia, Tnfrsf12a, Eif4g2, Ngfr, Map 1b, Stk25 | ||
| Regulation of transcription from RNA polymerase II promoter in response to stress (GO:0043618) | 5.23 | 2.69E-03 |
| Klf2, Jun, Psmd8, Xbp1, Cited2, Nfe2l2, Atf4, Ddit3, Bag3, Nedd4, Higd1a | ||
| Cellular response to topologically incorrect protein (GO:0035967) | 5.14 | 8.06E-04 |
| Calr, Derl2, Dnajb11, Xbp1, Arfgap1, Fkbp14, Nfe2l2, Atf4, Syvn1, Ddit3, Tln1, Bag3, Optn | ||
| Cell redox homeostasis (GO:0045454) | 5.14 | 4.57E-02 |
| Nnt, P4hb, Pdia3, Prdx1, Nfe2l2, Nqo1, Ddit3, Tmx1 | ||
| Endosome organization (GO:0007032) | 5.14 | 4.55E-02 |
| Rab5b, Tmem127, Vps25, Vps28, Vps4b, Chmp3, Plekhj1 | ||
| Rho protein signal transduction (GO:0007266) | 5.08 | 4.76E-02 |
| Arhgdia, Cdh13, Cfl1, Ngfr, Adgrg1, Cdc42ep3 | ||