Table 4.
Top 15 enriched gene ontology terms for transcription start sites that are downregulated upon loss of SOX10 in S16 cells, ranked by fold enrichment. Beneath each term is a list of the genes that contributed to the term’s enrichment
| Gene Ontology Term | Fold Enrichment | FDR-Corrected P-Value |
|---|---|---|
| Regulation of myelination (GO:0031641) | 17.54 | 1.41E-02 |
| Sox10, Lgi4, Mag, Ctsc, S100b, Mtmr2 | ||
| Myelination (GO:0042552) | 15.35 | 1.86E-07 |
| Mbp, Lpar1, Sox10, Bcas1, Serinc5, Lgi4, Mpz, Cd9, Mag, Dhh, Jam3, Mtmr2, Pmp22, Mal | ||
| Ensheathment of neurons (GO:0007272) | 15.06 | 1.16E-07 |
| Mbp, Lpar1, Sox10, Bcas1, Serinc5, Lgi4, Mpz, Cd9, Mag, Dhh, Jam3, Mtmr2, Pmp22, Mal | ||
| Axon ensheathment (GO:0008366) | 15.06 | 7.73E-08 |
| Mbp, Lpar1, Sox10, Bcas1, Serinc5, Lgi4, Mpz, Cd9, Mag, Dhh, Jam3, Mtmr2, Pmp22, Mal | ||
| Substantia nigra development (GO:0021762) | 13.35 | 3.88E-02 |
| Mbp, Ndrg2, Mag, Cnp, Ldha | ||
| Gliogenesis (GO:0042063) | 7.53 | 1.51E-04 |
| Lpar1, Sox10, Lgi4, Lamb1, Erbb3, App, Srgap2, Cd9, Adgrg1, Metrn, Mag, Cnp, S100b | ||
| Glial cell differentiation (GO:0010001) | 7.44 | 2.38E-03 |
| Lpar1, Sox10, Lgi4, Erbb3, App, Cd9, Metrn, Mag, Cnp, S100b | ||
| Regulation of supramolecular fiber organization (GO:1902903) | 4.84 | 2.53E-03 |
| Capg, Lpar1, Nav3, Mid1ip1, Arl2, Chadl, Tmsb10, Cryab, Arpc1a, App, Limch1, Sorbs3, Emilin1, S100a10 | ||
| Extracellular structure organization (GO:0043062) | 3.87 | 4.98E-02 |
| Lamb1, App, Col16a1, Itga6, Itgb8, Vwa1, Emilin1, Col6a1, Jam3, Col9a3, Ddr1 | ||
| Biological adhesion (GO:0022610) | 3.19 | 1.60E-03 |
| Lrrc4b, Cd81, Lamb1, Il1rap, Gldn, App, Col16a1, Mpz, Hepacam, Itga6, Srgap2, Clic1, Itgb8, Ttyh1, Ctnna3, Cd9, Sorbs3, Adgrg1, Emilin1, Mag, Cnn3, Col6a1, Jam3, Ddr1 | ||
| Cell adhesion (GO:0007155) | 3.07 | 2.72E-03 |
| Lrrc4b, Lamb1, Il1rap, Gldn, App, Col16a1, Mpz, Hepacam, Itga6, Srgap2, Clic1, Itgb8, Ttyh1, Ctnna3, Cd9, Sorbs3, Adgrg1, Emilin1, Mag, Cnn3, Col6a1, Jam3, Ddr1 | ||
| Neuron development (GO:0048666) | 2.9 | 2.82E-02 |
| Sema3b, Lgi4, Lamb1, Ahi1, Gldn, Gas7, App, Ngfr, Rps6ka5, Srgap2, Rab13, Ank3, Mag, Cnp, S100b, Jam3, Mtmr2, Dclk1, Sh3kbp1, Ddr1 | ||
| Regulation of cellular component movement (GO:0051270) | 2.79 | 1.48E-02 |
| Sema3b, Lpar1, Cd81, Nav3, Tmsb10, Lamb1, Srgap2, Erbb3, App, Itga6, Srgap2, Limch1, Rassf4, Ctnna3, Cd9, Adgrg1, Emilin1, Tgfbr3, Jam3, Snai2, Gpsm3, Mal | ||
| Cytoskeleton organization (GO:0007010) | 2.65 | 1.81E-02 |
| Capg, Tacc2, Arl2, Tmsb10, Cryab, Epb41l2, Arpc1a, Mical3, Arhgap26, Shroom2, Gas7, Ccser2, Marcks, Srgap2, Limch1, Rab13, Sorbs3, Tacc1, Ank3, Cnn3, Cnp, Diaph3, Sh3kbp1, Tubb2a | ||
| Plasma membrane bounded cell projection organization (GO:0120036) | 2.5 | 4.96E-02 |
| Sema3b, Lpar1, Lamb1, Ahi1, Gldn, Gas7, App, Itga6, Ngfr, Rps6ka5, Srgap2, Ttyh1, Rab13, Ank3, Mag, Cnp, S100b, Ehd4, Jam3, Mtmr2, Dclk1, Sh3kbp1, Ddr1, Pmp22 | ||