Table 1. Recommended Loading Dosages for Initiation and Dose Escalation of Sotalol Administration.

ClCra (mL/min)	IV loading dose (mg) to be administered over 1 h when the oral dose is going from				Minimum delay to first oral dose (h)	Oral dosing interval (h)
	Sotalol initiation		Sotalol escalation
	0 - 80 mgb	0 - 120 mg	80 - 120 mg	120 - 160 mg
> 90	60	90	75	90	4	12
60 - 90	82.5	125	82.5	105	4	12
30 - 60	75	112.5	82.5	105	6	24
10 - 30	75	112.5	82.5	105	12	48

^aCalculated using Cockcroft-Gault formula. ^bRecommended starting dose. ClCr: creatinine clearance; IV: intravenous.