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. 2020 May 4;107(3):573–589. doi: 10.1093/biomet/asaa016

Table 1.

Top ten most significant gene sets through which the TMED10 gene may act on drug response

Gene set Inline graphic CI Inline graphic-value
Regulation of heart rate Inline graphic Inline graphic
Synaptic vesicle cycle Inline graphic Inline graphic
Regulation of vasoconstriction Inline graphic Inline graphic
Negative regulation of transporter activity Inline graphic Inline graphic
Negative regulation of cation transmembrane transport Inline graphic Inline graphic
Positive regulation of blood circulation Inline graphic Inline graphic
Negative regulation of transmembrane transport Inline graphic Inline graphic
Regulation of cardiac muscle contraction Inline graphic Inline graphic
Neurotransmitter transport Inline graphic Inline graphic
Regulation of oxidoreductase activity Inline graphic Inline graphic

Inline graphic CI, confidence intervals obtained from the proposed method under incomplete mediation (6); Inline graphic-value, raw Inline graphic-values obtained from the proposed procedure.