Table 1.

Effect of ethanolic extract of Iris songarica (IS) on the plasma levels of AST, ALT, urea and creatinine

Groups	AST (U/L)	ALT (U/L)	Urea (mg/dl)	Creatinine (mg/dl)
Control	61.12±3.27###	59.00±4.59##	39.62±3.29###	0.68±0.06#
MTX	116.00±12.03***	77.25±7.70**	55.62±3.15***	0.82±0.07 *
MTX+IS50	71.75±9.05###	42.12±3.31***,###,&	46.37±6.23#	0.65±0.05 ##
MTX+IS150	69.12±5.11###,*	41.12±5.30***,###	37.71±4.71###	0.61±0.06 ##
MTX+IS300	73.62±6.04**,###	35.62±4.13***,###,†	38.37±3.42 ###	0.65±0.07 ##

Values are presented as mean ± SD (n=8). Data were analyzed by one-way ANOVA test followed by Dunnett's test. *p<0.05, **p<0.01 and ***p<0.001, show significant difference compared to control group. # p<0.05, ## p<0.01, and ### p<0.001, show significant difference compared to MTX group. ^&p<0.05, shows significant difference compared to IS300 group. †p<0.05, shows significant difference compared to IS50 group. MTX: methotrexate (20 mg/kg), IS50-IS300: ethanolic extract of Iris songarica at the doses of 50-300 mg/kg. AST: aspartate aminotransferase, ALT: alanine aminotransferase.