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. 2020 Jul 27;117(32):19359–19366. doi: 10.1073/pnas.1921719117

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Copyright © 2020 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 4. — TEs are infrequently located at TSSs but can generate enhancers when mutated. (A) TEs (SINEs, LINEs, and ERVs) are almost never located at TSSs. The y axes represent the ratios of TE-generated TSSs compared with all TSSs and are unit-less. The color of the axes represents each class of TE and matches the color of the corresponding curve displayed. (B) Compared with TSSs, TEs are more frequently located in enhancers. (C–E) Young TEs are rarely seen bearing enhancer elements whereas older (mutated) TEs slowly evolved into enhancer elements.