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. 2020 Jul 28;117(32):19446–19454. doi: 10.1073/pnas.2005540117

Fig. 3.

Fig. 3.

In vitro potential of horine (green) and verine (gold). (A) Horine and verine (2 × MIC) killed the exponential phase S. aureus USA300 LAC in 120 min. (B) The two peptides (2 × MIC) also killed nafcillin-induced persisters of S. aureus. (C) Verine, but not doripenem, inhibited the attachment of K. pneumoniae E406-17 in a dose-dependent manner. (D) Horine disrupted the 48-h established biofilms of S. aureus. In the confocal images, live bacteria in the untreated control are in green (E) and dead bacteria (F) treated at 16 µM of horine are in red. (G) Verine was effective in disrupting 48-h established Klebsiella biofilms. In the confocal images, live cells are green in untreated K. pneumoniae (H), and dead cells are red in verine-treated K. pneumoniae (I).