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. 2020 Jul 20;117(32):19328–19338. doi: 10.1073/pnas.2006038117

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Fig. 2. — Fixed and poly-LAVA insertions have similar and uneven genomic distribution. (A) LAVA insertions present at 100% frequency in the population were classified as fixed LAVA (blue), and the rest were classified as poly-LAVA (red). Circos plot (Upper) shows the nonhomogeneous distribution of fixed (blue) and poly-LAVA (red) insertions across the gibbon chromosomes. Chromosome numbers are annotated on the outer circle, and 11 inner circles represent the genomes of the 11 NLE gibbons included in this study. (B) Proportion of LAVA observed in different positions with respect to genes is shown in bold, and mean ± SD expected percentages are reported below. *Significant deviation from expectation (permutation P < 0.01). UTR, untranslated region. (C) Correlations between gene density and LAVA density (counts per megabase) are shown across chromosomes for fixed (blue) and poly-LAVA (red).