Extended Data Figure 4. Pfam protein families enrichments for SARS-CoV-2 host factors.

The enrichment of individual PFAM domains was calculated using a hypergeometric test where success is defined as the number of domains, and the number of trials is the number of individual preys affinity purified with each viral bait. The population values were the numbers of individual PFAM domains in the human proteome. The p-values were not adjusted for multiple testing. To make sure that the p-values that signify enrichment were meaningful, we only considered PFAM domains that have been affinity purified at least three times with any SARS-CoV-2 protein, and which occur in the human proteome at least five times. Here, we show PFAM domains with the lowest p-value for a given viral bait protein.