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. Author manuscript; available in PMC: 2020 Oct 30.
Published in final edited form as: Nature. 2020 Apr 30;583(7816):459–468. doi: 10.1038/s41586-020-2286-9

Extended Data Figure 5. Lung mRNA expression and specificity of SARS-CoV-2-interacting human proteins relative to other proteins.

Extended Data Figure 5.

(a) Scatterplot of the lung mRNA expression (TPM) versus enrichment of lung mRNA expression (lung TPM/median all tissue TPM) for human interacting proteins. Red points denote drug targets that are labeled with their gene names. Points above the horizontal blue line represent interacting proteins that are enriched in lung expression and show how most SARS-CoV-2 interacting proteins tend to be enriched in the lung. (b) Gene expression in the lung of the high-confidence human interacting proteins was observed to be higher when compared to all other proteins (blue=interacting proteins; n=332; median=25.52 TPM; grey=all other proteins; n=13583; median=3.198 TPM, p=.0007 using a t-test).