TABLE 1.

PTMs reported in select domains of fodrin and spectrin^a

Type of PTM	Domain	Subunit	Position(s) (reference[s])
Phosphorylation	SH3	α-Fodrin	Y976-p (91), Y978-p (92), S982-p (93–97), T995-p (98), S999-p (93), T1000-p (99), Y1020-p, S1029-p (98, 100–103)
		α-Spectrin	Y986-p, S992-p (95, 104, 105)
	CaM binding domain	α-Fodrin	Y1176-p (91, 106–111), T1184-p, S1186-p (112), T1188-p (112, 113), S1190-p (93, 94, 98, 104, 108, 112, 114–117), S1194-p (94, 118), T1204-p (95, 101), S1207-p (101), S1217-p (119), S1226-p (95, 98), S1231-p (94, 95, 98, 101)
	EF hands	α-Fodrin	S2411-p, T2425-p, T2434-p, Y2423-p (120), Y2430-p, Y2440-p (121)
		α-Spectrin	T2288-p (98), Y2333-p, S2335-p (95), S2405-p, Y2407-p
	CH domain	β-Fodrin	S163-p (93), S228-p (93, 95), S257-p (112), S278-p, S96-p (108), T80-p (92), Y274-p, Y79-p (92)
		β-Spectrin	S96-p (122), T104-p (104), T152-p, T76-p (123)
	PH domain	β-Fodrin	S2221-p, S2251-p, S2303-p, T2297-p, Y2249-p (110), Y2268-p (124), Y2285-p (92)
Acetylation	SH3	α-Fodrin	K1022-ac (125), K1023-ac
	EF hands	α-Fodrin	K2421-ac (125), K2426-ac (125)
	CH domain	β-Fodrin	K124-ac (125), K90-ac (125)
		β-Spectrin	K80-ac
	PH domain	β-Fodrin	K2207-ac, K2269-ac, K2270-ac
Ubiquitination	SH3	α-Fodrin	K990-ub (126, 127)
	CaM binding domain	α-Fodrin	K1187-ub (128), K1193-ub (127, 129), K1209-ub (129)
	EF hands	α-Fodrin	K2404-ub (126), K2421-ub (126), K2426-ub (129, 130)
	CH domain	β-Fodrin	K214-ub (126), K227-ub (127), K249-ub (126), K62-ub (129, 130), K118-ub (126, 127), K124-ub (118)
		β-Spectrin	K102-ub, K107-ub, K118-ub (126, 127), K124-ac (125, 131), K124-ub (118), K62-ub (130)
	PH domain	β-Fodrin	K2207-ub (126), K2241-ub (129), K2276-ub (127)
Sumoylation	CH domain	β-Fodrin	K214-sm (132)

^aCaM, calmodulin. p, phosphorylation; ac, acetylation; ub, ubiquitination; sm, sumoylation; CH, calponin homology domain; PH, pleckstrin homology domain.