Fig. 6.

C8 reduces growth rates of C8-sensitive but not C8-resistant cancer cell lines in mouse tumor models. Tumor volumes in mouse xenograft models established using C8-resistant cancer cells (MDA-MB-231) (A) and C8-sensitive cancer cells (HCC1806 and HCT116) (B and C). Compared with vehicle, twice-daily treatment with 20 mg/kg C8 significantly reduced tumor volumes in the HCC1806 (P = 0.03) and HCT116 (P = 0.02) mouse models but showed no effect in the MDA-MB-231 mouse model. Mean tumor volumes for each group are plotted, and error bars represent the SEM. An asterisk indicates tumor volume distributions that are significantly different with P < 0.05.