Table 2. Accuracy of prediction of F-actin in mouse kidney tissue as a function of input channels.

Median values of the Pearson correlation (r) and structural similarity index (SSIM) between predicted and target volumes of F-actin. We evaluated combinations of brightfield (BF), phase (Φ), retardance (ρ), orientation x (ω_x), and orientation y (ω_y), as input. Model training conditions and computation of test metrics is described in Table 1.

Translation model	Input(s)	rxy	rxz	rxyz	SSIMxy	SSIMxz	SSIMxyz
Stack→Slice (2.5D, $z=5$)	ρ	0.86	0.84	0.87	0.81	0.76	0.82
	BF	0.86	0.84	0.86	0.82	0.77	0.83
	Φ	0.87	0.85	0.88	0.83	0.78	0.84
	Φ, ρ, ωx, ωy	0.88	0.87	0.89	0.83	0.80	0.85
	BF, ρ, ωx, ωy	0.88	0.87	0.89	0.83	0.79	0.85