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. 2020 Aug 6;11(8):e00224. doi: 10.14309/ctg.0000000000000224

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© 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work, provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 6. — Microbiota related to the long-term efficacy of FMT in patients with UC. (a) The partial Mayo score of the 22 patients at various visits (pre-FMT, 1 week post-FMT and 1 month post-FMT). The 7 patients (boxed) achieved clinical remission and maintaining time was at least 4 months. (b and c) Beta diversity was calculated by MDS and CAP coordinates in the remission (R) and nonremission (NR) groups. Each dot stands for 1 sample. (d–f) The relative abundance differences of genera Eggerthella (r = 0.542, P = 0.014), Lactobacillus (r = 0.471, P = 0.036), and Ruminococcus (r = 0.523, P = 0.018) between pre-FMT and 5 days post-FMT were positively correlated to the long-term efficacy (4 months after FMT) significantly. P value less than 0.05 was considered statistically significant. The number of samples: Rdonor (n = 7), NRdonor (n = 12), Rpre (n = 7), NRpre (n = 15), Rpost (n = 5), and NRpost (n = 15). CAP, canonical analysis of principal; FMT, fecal microbiota transplantation; NRpre, genera in the nonremission group before FMT; NRpost, genera in the nonremission group after FMT; Rdonor, genera in the remission group of donor; Rpre, relative abundance of genera in the remission group before FMT; Rpost, genera in the remission group after FMT; MDS, multidimensional scaling; NRdonor, genera in the nonremission group of donor; UC, ulcerative colitis.