Table 3.
The boxes in the leftmost column show the original cutoff values. Keeping each index constant in turn (bold), the cutoff values are optimized to minimize discrepancy. With each set of new cutoff values, the percentage of patients classified into discrepant disease states is also shown.
| Original criteria | Adjusted criteria | |||
|---|---|---|---|---|
|
| ||||
| DAS28-ESR | DAS28-CRP | CDAI | SDAI | |
| DAS28-ESR | ||||
| Remission: <2.6 | Remission: <2.0 | Remission: <2.7 | Remission: <3 | |
| Low activity: 2.6 to ≤3.2 | Low activity: 2.0 to ≤2.8 | Low activity: 2.7 to ≤8 | Low activity: 3 to ≤8 | |
| Moderate activity: 3.2 to ≤5.1 | Moderate activity: 2.8 to ≤4.68 | Moderate activity: 8 to ≤27 | Moderate activity: 8 to ≤30 | |
| High activity: >5.1 | High activity: >4.68 | High activity: >27 | High activity: >30 | |
| Discrepancy: 15.4% | Discrepancy: 29.1% | Discrepancy: 28.0% | ||
| DAS28-CRP | ||||
| Remission: <2.6 | Remission: <3.24 | Remission: <7.3 | Remission: <8.4 | |
| Low activity: 2.6 to ≤3.2 | Low activity: 3.24 to ≤3.5 | Low activity: 7.3 to ≤8 | Low activity: 8.4 to ≤10.9 | |
| Moderate activity: 3.2 to ≤5.1 | Moderate activity: 3.5 to ≤5.8 | Moderate activity: 8 to ≤34 | Moderate activity: 10.9 to ≤34 | |
| High activity: >5.1 | High activity: >5.8 | High activity: >34 | High activity: >34 | |
| Discrepancy: 18.9% | Discrepancy: 19.4% | Discrepancy: 20.6% | ||
| CDAI | ||||
| Remission ≤2.8 | Remission: <1.5 | Remission: <2.1 | Remission: <5 | |
| Low activity 2.8 to ≤10 | Low activity: 1.5 to ≤3.6 | Low activity: 2.1 to ≤3.2 | Low activity: 5 to ≤10.5 | |
| Moderate activity: 10 to ≤22 | Moderate activity: 3.6 to ≤5.4 | Moderate activity: 3.2 to ≤4.5 | Moderate activity: 10.5 to ≤24.5 | |
| High activity >22 | High activity: >5.4 | High activity: >4.5 | High activity: >24.5 | |
| Discrepancy: 32.6% | Discrepancy: 26.9% | Discrepancy: 8.0% | ||
| SDAI | ||||
| Remission ≤ 3.3 | Remission: <1.4 | Remission: <1.3 | Remission: <2.7 | |
| Low activity 3.3 to ≤11 | Low activity: 1.4 to ≤3.5 | Low activity: 1.3 to ≤3.1 | Low activity: 2.7 to ≤9.5 | |
| Moderate activity: 11 to ≤26 | Moderate activity: 3.5 to ≤5.42 | Moderate activity: 3.1 to ≤4.5 | Moderate activity: 9.5 to ≤23 | |
| High activity >26 | High activity: >5.42 | High activity: >4.5 | High activity: >23 | |
| Discrepancy: 26.9% | Discrepancy: 25.1% | Discrepancy: 6.3% | ||
CDAI: clinical disease activity index; CRP: C-reactive protein; DAS: disease activity score; ESR: erythrocyte sedimentation rate; SDAI: simple disease activity index.