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. Author manuscript; available in PMC: 2020 Aug 22.
Published in final edited form as: ACS Chem Neurosci. 2020 Feb 18;11(16):2450–2463. doi: 10.1021/acschemneuro.9b00674

Table 4.

Pharmacokinetic studies in mice*

No. [Plasma]
(ng/mL)		 [Brain]
(ng/g)		 AUCBrain
(ng*hr/g)		 AUCPlasma
(ng*hr/mL)		 AUCBrain/AUCPlasma
0.5 2 4 7 0.5 2 4 7
2 110 138 10.2 - 53.6 - - - 53.6 376 0.14
4 141 17.3 7.4 3.1 90.8 16.1 - - 119 195 0.61
50 1,530 57.7 4.7 11.4 671 82.5 12.5 13.8 868 1660 0.52
62 473 200 65.9 14.3 36.1 32 16.6 12.4 152 1010 0.15
*

Compounds were administered as a single IP dose at 10 mg/kg.