Table 2.
GO enrichment analysis of ESCA-related DEGs.
| Category | Term | Annotation | Count | P Value | FDR |
|---|---|---|---|---|---|
| MF | GO: 0042393 | Histone binding | 5 | 0.040956 | 43.57063 |
| GO: 0004672 | Protein kinase activity | 9 | 0.037858 | 41.02474 | |
| GO: 0017048 | Rho GTPase binding | 3 | 0.035287 | 38.83208 | |
| GO: 0008083 | Growth factor activity | 6 | 0.029217 | 33.3507 | |
| GO: 0003678 | DNA helicase activity | 3 | 0.026484 | 30.73641 | |
| GO: 0042826 | Histone deacetylase binding | 5 | 0.023265 | 27.53669 | |
| GO: 0019901 | Protein kinase binding | 10 | 0.019069 | 23.15887 | |
| GO: 0016887 | ATPase activity | 7 | 0.013453 | 16.91675 | |
| GO: 0048407 | Platelet-derived growth factor binding | 3 | 0.005775 | 7.618473 | |
| GO: 0005201 | Extracellular matrix structural constituent | 5 | 0.005574 | 7.362384 | |
| GO: 0005524 | ATP binding | 28 | 0.004315 | 5.745381 | |
| GO: 0008574 | ATP-dependent microtubule motor activity, plus-end-directed | 4 | 7.15E-04 | 0.97331 | |
| GO: 0008017 | Microtubule binding | 10 | 3.85E-04 | 0.525754 | |
| GO: 0008201 | Heparin binding | 9 | 3.10E-04 | 0.423032 | |
| GO: 0003777 | Microtubule motor activity | 7 | 2.05E-04 | 0.280292 | |
| GO: 0005515 | Protein binding | 118 | 1.98E-04 | 0.271172 | |
| GO: 0008307 | Structural constituent of muscle | 6 | 7.85E-05 | 0.107306 | |
| GO: 0003779 | Actin binding | 15 | 1.63E-06 | 0.002223 | |
| CC | GO: 0005814 | Centriole | 5 | 0.034311 | 36.49999 |
| GO: 0097149 | Centralspindlin complex | 2 | 0.032082 | 34.56688 | |
| GO: 0005694 | Chromosome | 5 | 0.0272 | 30.14128 | |
| GO: 0070062 | Extracellular exosome | 42 | 0.0257 | 28.72761 | |
| GO: 0005680 | Anaphase-promoting complex | 3 | 0.025342 | 28.38631 | |
| GO: 0005584 | Collagen type i trimer | 2 | 0.021504 | 24.62943 | |
| GO: 0016363 | Nuclear matrix | 5 | 0.021056 | 24.17972 | |
| GO: 0051233 | Spindle midzone | 3 | 0.017618 | 20.64245 | |
| GO: 0005925 | Focal adhesion | 11 | 0.010247 | 12.53825 | |
| GO: 0015629 | Actin cytoskeleton | 8 | 0.009682 | 11.8868 | |
| GO: 0005654 | Nucleoplasm | 44 | 0.008794 | 10.8543 | |
| GO: 0005576 | Extracellular region | 29 | 0.008174 | 10.12583 | |
| GO: 0048471 | Perinuclear region of cytoplasm | 15 | 0.007728 | 9.598831 | |
| GO: 0005813 | Centrosome | 12 | 0.006822 | 8.519486 | |
| GO: 0000922 | Spindle pole | 6 | 0.006621 | 8.277421 | |
| GO: 0015630 | Microtubule cytoskeleton | 7 | 0.003771 | 4.795012 | |
| GO: 0001725 | Stress fiber | 5 | 0.002747 | 3.514485 | |
| GO: 0045120 | Pronucleus | 3 | 0.002356 | 3.021411 | |
| GO: 0005737 | Cytoplasm | 77 | 0.001617 | 2.083603 | |
| GO: 0005829 | Cytosol | 54 | 0.00154 | 1.984823 | |
| GO: 0031012 | Extracellular matrix | 11 | 0.001477 | 1.904168 | |
| GO: 0005876 | Spindle microtubule | 5 | 0.001282 | 1.655013 | |
| GO: 0031262 | Ndc80 complex | 3 | 6.88E-04 | 0.890813 | |
| GO: 0000942 | Condensed nuclear chromosome Outer kinetochore | 3 | 6.88E-04 | 0.890813 | |
| GO: 0005874 | Microtubule | 12 | 5.90E-04 | 0.765086 | |
| GO: 0030018 | Z disc | 8 | 2.97E-04 | 0.385939 | |
| GO: 0005581 | Collagen trimer | 8 | 6.25E-05 | 0.081295 | |
| GO: 0000776 | Kinetochore | 8 | 2.74E-05 | 0.035668 | |
| GO: 0005871 | Kinesin complex | 7 | 2.22E-05 | 0.028929 | |
| GO: 0005615 | Extracellular space | 33 | 2.02E-05 | 0.026247 | |
| GO: 0005578 | Proteinaceous extracellular matrix | 14 | 7.32E-06 | 0.009524 | |
| GO: 0005819 | Spindle | 10 | 6.68E-06 | 0.008694 | |
| GO: 0000775 | Chromosome, centromeric region | 8 | 2.59E-06 | 0.003375 | |
| GO: 0030496 | Midbody | 11 | 1.40E-06 | 0.001819 | |
| GO: 0000777 | Condensed chromosome kinetochore | 11 | 3.37E-08 | 4.38E-05 | |
| BP | GO: 0007015 | Actin filament organization | 4 | 0.048188 | 55.68998 |
| GO: 0051436 | Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 4 | 0.046554 | 54.41983 | |
| GO: 0001666 | Response to hypoxia | 6 | 0.046026 | 54.00186 | |
| GO: 0046777 | Protein autophosphorylation | 6 | 0.046026 | 54.00186 | |
| GO: 0044344 | Cellular response to fibroblast growth factor stimulus | 3 | 0.045033 | 53.20648 | |
| GO: 2000660 | Negative regulation of interleukin-1-mediated signaling pathway | 2 | 0.044501 | 52.77484 | |
| GO: 0010574 | Regulation of vascular endothelial growth factor production | 2 | 0.044501 | 52.77484 | |
| GO: 0043154 | Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 4 | 0.043372 | 51.8463 | |
| GO: 0097421 | Liver regeneration | 3 | 0.042339 | 50.98273 | |
| GO: 0051384 | Response to glucocorticoid | 4 | 0.037348 | 46.59797 | |
| GO: 0060326 | Cell chemotaxis | 4 | 0.037348 | 46.59797 | |
| GO: 0007049 | Cell cycle | 7 | 0.037147 | 46.41426 | |
| GO: 0045840 | Positive regulation of mitotic nuclear division | 3 | 0.034645 | 44.07219 | |
| GO: 0071173 | Spindle assembly checkpoint | 2 | 0.033564 | 43.03115 | |
| GO: 0060414 | Aorta smooth muscle tissue morphogenesis | 2 | 0.033564 | 43.03115 | |
| GO: 0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | 4 | 0.033134 | 42.61195 | |
| GO: 0000070 | Mitotic sister chromatid segregation | 3 | 0.032215 | 41.70664 | |
| GO: 0006306 | DNA methylation | 3 | 0.032215 | 41.70664 | |
| GO: 0042787 | Protein ubiquitination involved in ubiquitin-dependent protein catabolic process | 6 | 0.030104 | 39.57493 | |
| GO: 0051966 | Regulation of synaptic transmission, glutamatergic | 3 | 0.02757 | 36.92013 | |
| GO: 0051439 | Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 3 | 0.02757 | 36.92013 | |
| GO: 0043547 | Positive regulation of GTPase activity | 13 | 0.027349 | 36.68291 | |
| GO: 0070301 | Cellular response to hydrogen peroxide | 4 | 0.026698 | 35.9813 | |
| GO: 1903779 | Regulation of cardiac conduction | 4 | 0.0255 | 34.66984 | |
| GO: 0008283 | Cell proliferation | 10 | 0.023601 | 32.53933 | |
| GO: 0048146 | Positive regulation of fibroblast proliferation | 4 | 0.023193 | 32.07322 | |
| GO: 0000022 | Mitotic spindle elongation | 2 | 0.022502 | 31.27789 | |
| GO: 0001501 | Skeletal system development | 6 | 0.019827 | 28.11186 | |
| GO: 0010881 | Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ions | 3 | 0.019192 | 27.33961 | |
| GO: 0006939 | Smooth muscle contraction | 3 | 0.017299 | 24.99359 | |
| GO: 0051726 | Cell cycle regulation | 6 | 0.013422 | 19.96503 | |
| GO: 0031145 | Anaphase-promoting complex-dependent catabolic process | 5 | 0.012345 | 18.5125 | |
| GO: 0006957 | Complement activation, alternative pathway | 3 | 0.009152 | 14.06012 | |
| GO: 0051310 | Metaphase plate congression | 3 | 0.007801 | 12.10953 | |
| GO: 0055119 | Relaxation of cardiac muscle | 3 | 0.007801 | 12.10953 | |
| GO: 0048565 | Digestive tract development | 4 | 0.007152 | 11.1566 | |
| GO: 0008284 | Positive regulation of cell proliferation | 13 | 0.006888 | 10.76681 | |
| GO: 0030574 | Collagen catabolic process | 5 | 0.005947 | 9.363414 | |
| GO: 0034501 | Protein localization to kinetochore | 3 | 0.005399 | 8.535467 | |
| GO: 0032060 | Bleb assembly | 3 | 0.005399 | 8.535467 | |
| GO: 0007019 | Microtubule depolymerization | 3 | 0.005399 | 8.535467 | |
| GO: 0006268 | DNA unwinding involved in DNA replication | 3 | 0.005399 | 8.535467 | |
| GO: 0009612 | Response to mechanical stimulus | 5 | 0.00445 | 7.087078 | |
| GO: 0071549 | Cellular response to dexamethasone stimulus | 4 | 0.004196 | 6.694943 | |
| GO: 0019221 | Cytokine-mediated signaling pathway | 7 | 0.003769 | 6.034147 | |
| GO: 0032355 | Response to estradiol | 6 | 0.00373 | 5.973802 | |
| GO: 0001558 | Regulation of cell growth | 6 | 0.00213 | 3.453634 | |
| GO: 0000910 | Cytokinesis | 5 | 0.002095 | 3.397158 | |
| GO: 0007094 | Mitotic spindle assembly checkpoint | 4 | 0.00141 | 2.299434 | |
| GO: 0000086 | G2/M transition of mitotic cell cycle | 8 | 9.49E-04 | 1.552707 | |
| GO: 0007080 | Mitotic metaphase plate congression | 5 | 7.83E-04 | 1.283031 | |
| GO: 0007155 | Cell adhesion | 15 | 7.52E-04 | 1.232171 | |
| GO: 0007018 | Microtubule-based movement | 7 | 3.11E-04 | 0.511889 | |
| GO: 0030199 | Collagen fibril organization | 6 | 7.41E-05 | 0.122099 | |
| GO: 0006936 | Muscle contraction | 9 | 2.91E-05 | 0.047888 | |
| GO: 0007052 | Mitotic spindle organization | 6 | 1.99E-05 | 0.032833 | |
| GO: 0000281 | Mitotic cytokinesis | 6 | 1.68E-05 | 0.027614 | |
| GO: 0007059 | Chromosome segregation | 8 | 1.15E-05 | 0.018962 | |
| GO: 0007062 | Sister chromatid cohesion | 12 | 2.35E-08 | 3.87E-05 | |
| GO: 0007067 | Mitotic nuclear division | 20 | 5.66E-11 | 9.33E-08 | |
| GO: 0051301 | Cell division | 25 | 1.55E-12 | 2.55E-09 |