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. 2020 Aug 17;11:4111. doi: 10.1038/s41467-020-17873-3

Fig. 3. HIF-1α and HIF-2α deletion affect different transcriptional programmes and inflammatory responses.

Fig. 3

a Principal component analysis of RNA sequencing of WT Cortex and VpR, VpRH1, and VpRH2 tumours. Gene expression heatmaps for selected differentially regulated genes from the indicated GSEA terms glycolysis (b), cell adhesion molecules (c), focal adhesion and receptor signalling (d), DNA repair (e), lipoprotein metabolism (f), ribosome biogenesis (g), T-cell activation (h), and response to IFN-β (i). Rows represent row-normalised z-scores of mRNA abundance, each column represents an individual sample from WT cortex or VpR, VpRH1, and VpRH2 tumours. Source data is provided in Supplementary Data 1 and 2.