Table 2.

Univariate Cox regression analysis of overall survival in breast cancer patients in the primary cohort.

Variable	HR (95% CI)	P value
Age at diagnosis (years)	1.01 (0.95–1.06)	0.74
Tumor size (mm)	1.03 (1.01–1.04)	0.002
Lymph node metastasis (pos vs. neg)	4.71 (1.24–17.81)	0.026
Distant metastasis (pos vs. neg)	4.57 (1.17–17.77)	0.029
ER status (pos vs. neg)	0.54 (0.16.–1.79)	0.32
P status (pos vs. neg)	0.40 (0.12–1.38)	0.15
HER2 positivity (pos vs. neg)	1.80 (0.49–6.42)	0.38
TNM staging (III/IV vs I/II)	6.54 (1.83–23)	0.003
DIO3 status (neg vs. pos)	4.29 (1.24–14.7)	0.021

HR hazard ratio, CI confidence interval, ER estrogen receptor, P progesterone, HER2 human epidermal growth factor receptor2.