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. 2020 Aug 17;10:13857. doi: 10.1038/s41598-020-70974-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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First trimester maternal serum metabolomic profiles of Eo-HDP-affected and healthy pregnancies. (a) PCA. Plots show the PCA scores obtained from maternal serum samples. Metabolically similar samples are located close to one other in the score plot. The x-axis indicates the main PC and the y-axis indicates the secondary PC. Each PC represents an axis in multidimensional space and corresponds to the direction of maximum variation in the original data. Numbers in parentheses indicate the contribution rates of each PC. (b): HCA. Rows and columns indicate metabolites and cases, respectively. Relative metabolite levels are represented in different colours, with red and green indicating increased and decreased levels, respectively.