Table 1.
Definitions of polyglandular autoimmune syndrome type II and type III across the studies included
| Article | Polyglandular autoimmune syndrome type II | Polyglandular autoimmune syndrome type III |
|---|---|---|
| Abrar-Ahmad [29] | AD and AITD and/or T1DM and other autoimmunities |
The absence of adrenal insufficiency III/a-AITD and T1DM and sarcoidosis or coeliac disease III/b-AITD and pernicious anemia III/c-AITD and vitiligo or alopecia |
| Ben-Skowronek et al. [27] | AD and AITD and/or T1DM |
AITD plus other endocrinopathy except for AD III/A-AITD and T1DM III/B-AITD and pernicious anemia III/c-AITD and vitiligo and/or alopecia and/or other organ-specific autoimmune diseases |
| Betterle et al. [31] | AD and AITD and/or T1DM | AITD and other autoimmune diseases excluding AD and/or hypoparathyroidism |
| Cruz et al. [20] | AD and AITD and/or T1DM | PAS type III differs from type II by the absence of AD |
| Dittmar and Kahaly [21] | AD and AITD and/or T1DM | Apart from the absence of AD, there is no clinical difference between PAS type II and type III |
| Horie et al. [23] | a | AITD and T1DM |
| Papadopoulos and Hallengren [25] | AD and AITD and/or T1DM without hypoparathyroidism or chronic mucocutaneous candidiasis | a |
| Papadopoulos et al. [26] | AD and AITD and/or T1DM | AITD and T1DM and/or pernicious anemia and/or vitiligo/alopecia |
| Piatkowska and Szalecki [22] | a | AITD and at least one of autoimmune disease: T1DM, pernicious anemia, vitiligo, alopecia areata, coeliac disease, hypogonadism, myasthenia gravis and others excluding AD |
| Sastre-Garriga [28] | AD and AITD and/or T1DM for primary criteria, secondary criteria can be gonadal failure, vitiligo, alopecia and pernicious anemia | a |
| Storz et al. [35] | AD and AITD and/or T1DM | AD excluded |
| Choudhuri et al. [19], Handa and Dogra [34], Karagüzel et al. [32], Karavanaki et al. [33], Kondonouri et al. [26], Renzullo et al. [3], Teufel et al. [30] | a | a |
aNo definition given in the study, we characterized the subgroups, as follows: polyglandular autoimmune syndrome type II: Addison’s disease and autoimmune thyroid disease and/or type I diabetes mellitus; polyglandular autoimmune syndrome type III: autoimmune thyroid disorders and other autoimmune diseases except Addison’s disease
AD Addison’s disease, AITD autoimmune thyroid disorders, PAS polyglandular autoimmune syndrome, T1DM type 1 diabetes mellitus