Table 2.
Determination of MIC of Cryptotanshinone and Fosfomycin Alone or in Combination Against FSSA and FRSA
| Pathogen | Strain | Agent | MIC Alone (μg/mL) | MIC Combination (μg/mL) | FIC | FICI | Outcome |
|---|---|---|---|---|---|---|---|
| S. aureus | ATCC25923 | Cryptotanshinone | 8 | 2 | 0.25 | 0.3125 | Synergistic |
| Fosfomycin | 2 | 0.125 | 0.0625 | ||||
| #25 | Cryptotanshinone | 8 | 1 | 0.125 | 0.625 | Partialsynergy | |
| Fosfomycin | 128 | 64 | 0.5 | ||||
| #28 | Cryptotanshinone | 8 | 1 | 0.125 | 0.375 | Synergistic | |
| Fosfomycin | 64 | 16 | 0.25 | ||||
| #47 | Cryptotanshinone | 8 | 1 | 0.125 | 0.375 | Synergistic | |
| Fosfomycin | 64 | 16 | 0.25 | ||||
| #87 | Cryptotanshinone | 8 | 1 | 0.125 | 0.375 | Synergistic | |
| Fosfomycin | 64 | 16 | 0.25 | ||||
| #99 | Cryptotanshinone | 8 | 0.5 | 0.0625 | 0.5625 | Partialsynergy | |
| Fosfomycin | 128 | 32 | 0.5 | ||||
| #122 | Cryptotanshinone | 128 | 32 | 0.25 | 0.3125 | Synergistic | |
| Fosfomycin | 2048 | 128 | 0.0625 | ||||
| #133 | Cryptotanshinone | 128 | 32 | 0.25 | 0.3125 | Synergistic | |
| Fosfomycin | 2048 | 128 | 0.0625 |