Table 3.

Activity of Sarecycline and Comparator Agents Against Isolates of Gram-Negative Bacteria

Organism	Agent	MIC (μg/mL)
		Range	50%	90%
E. cloacae	Sarecycline	0.25 to >64	32	>64
	Tetracycline	0.5 to >64	2	>64
	Doxycycline	0.96 to >32	2	32
	Minocycline	≤0.03 to >32	1	16
E. coli	Sarecycline	2 to >64	16	>64
	Tetracycline	1 to >64	2	>64
	Doxycycline	0.5 to >32	2	32
	Minocycline	0.25 to >32	1	8
K. pneumoniae	Sarecycline	16 to >64	>64	>64
	Tetracycline	1 to >64	8	>64
	Doxycycline	1 to >32	8	>32
	Minocycline	1 to >32	4	>32
P. mirabilis	Sarecycline	>64	>64	>64
	Tetracycline	16 to >64	32	64
	Doxycycline	32 to >32	>32	>32
	Minocycline	8 to >32	16	>32
Salmonella spp.	Sarecycline	8 to >64	16	>64
	Tetracycline	1 to >64	2	>64
	Doxycycline	2 to >32	2	32
	Minocycline	1 to >32	2	8

Note: Reproduced from Zhanel G, Critchley I, Lin LY, Alvandi N. Microbiological profile of sarecycline, a novel targeted spectrum tetracycline for the treatment of acne vulgaris. Antimicrob Agents Chemother. 2019;63:1. Creative Commons license and disclaimer available from: http://creativecommons.org/licenses/by/4.0/legalcode.19