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. 2020 Aug 11;8:713. doi: 10.3389/fcell.2020.00713

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Copyright © 2020 Liu, Hu, Cai, Xie, Yuan, Li, Xie, Yao, Zhao, Wu and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nucleotide-binding oligomerization domain-like receptor 3 (NLRP3) deficiency alleviated the cardiac fibrosis and inflammation induced by isoproterenol. (A) Images of hematoxylin and eosin, picrosirius red, and immunohistochemistry staining for CD45, CD68 of each group (n = 6). (B) Statistical results for the heart weight/body weight (n = 12). (C) Cross-sectional area results of cardiomyocyte in the indicated group (n = 6, 100 + cells per group). (D–F) Quantitative results of picrosirius red, CD45, CD68 staining (n = 6). (G) Relative messenger RNA levels of transforming growth factor β, connective tissue growth factor, collagen Ia, and collagen III in mice heart (n = 6). *P < 0.05 vs. sham + wild type, ^#P < 0.05 vs. isoproterenol + wild type.