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. 2020 Aug 11;8:713. doi: 10.3389/fcell.2020.00713

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Copyright © 2020 Liu, Hu, Cai, Xie, Yuan, Li, Xie, Yao, Zhao, Wu and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nucleotide-binding oligomerization domain-like receptor 3 (NLRP3) overexpression enhanced the nuclear translocation and secretion of HMGB1 in neonatal rat ventricular myocytes. (A) Immunofluorescence staining of HMGB1 neonatal rat ventricular myocytes treated with Ad-NLRP3 or Ad-NC and ISO or phosphate-buffered saline (n = 6). (B) HMGB1 content in NRVMs supernatant of each group (n = 6). (C) Messenger RNA expression of HMGB1 of each group (n = 6). (D–G) Protein expression of whole-cell, nucleus, and cytoplasm HMGB1 in neonatal rat ventricular myocytes of the indicated group. Western blot images (D) and quantitative results (E–G) (n = 6). *P < 0.05 vs. phosphate-buffered saline + Ad-NC, ^#P < 0.05 vs. ISO + Ad-NC.