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. 2020 Aug 11;12:230. doi: 10.3389/fnagi.2020.00230

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Copyright © 2020 Calabrese, Di Maio, Marino, Cardinale, Natale, De Rosa, Campanelli, Mancini, Napolitano, Avallone, Calabresi, Usiello, Ghiglieri and Picconi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histochemical and biochemical characterization. (A) Schematic experimental protocol. (B) Tyrosine hydroxylase immunostaining in coronal section of Substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) regions of 6-hydroxydopamine (6-OHDA)-lesioned rats treated with Levodopa (L-DOPA) or rapamycin + L-DOPA (2× objective, scale bar 500 μm). (C) The graphs show the percentage of loss of TH+ cells (compared to contralateral side), in the ipsilateral side of L-DOPA or rapamycin + L-DOPA-treated rats, respectively, in the SNc region (C, left panel; p = 0.2957) and VTA region (C, right panel; p = 0.5757). Data were expressed as mean ± SEM and analyzed by a two-tailed t-test.