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. 2020 Aug 11;12:230. doi: 10.3389/fnagi.2020.00230

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Copyright © 2020 Calabrese, Di Maio, Marino, Cardinale, Natale, De Rosa, Campanelli, Mancini, Napolitano, Avallone, Calabresi, Usiello, Ghiglieri and Picconi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic diagram illustrating (A) striatal D1/cAMP/PKA, pERK, and mTOR signaling cascade in a rat model of L-DOPA-induced dyskinesia; (B) the selective effect of rapamycin on mTORC1 signaling in a rat model of L-DOPA-induced dyskinesia.