Table 5.
Analysis of poor outcome and clinical features.
| Univariate analysis, mean (IQR) | |||
|---|---|---|---|
| Variable | No poor outcome (n = 193) | Poor outcome† (n = 25) | P-value |
| Age, y | 40.9 (30.0–50.0) | 58.4 (49.0–67.5) | 0.000 |
| Men, % | 107 (55%) | 15 (60%) | 0.831 |
| Clinical classification | 0.000 | ||
| Critical cases | 0 | 14 (56%) | ·· |
| Severe cases | 13 (7%) | 11 (44%) | ·· |
| Moderate cases | 146 (76%) | 0 | ·· |
| Mild cases | 10 (5%) | 0 | ·· |
| Asymptomatic cases | 24 (12%) | 0 | ·· |
| Leucocytes, × 109/L | 5.87 ± 3.19 | 6.34 ± 3.50 | 0.493 |
| Lymphocytes, × 109/L | 1.31 ± 0.61 | 0.80 ± 0.34 | 0.000 |
| APTT, s | 23.89 ± 16.71 | 39.17 ± 33.99 | 0.045 |
| ALT, U/L | 27.81 ± 22.57 | 28.40 ± 13.37 | 0.899 |
| AST, U/L | 27.12 ± 13.78 | 32.22 ± 11.02 | 0.078 |
| Scr, μmol/L | 71.78 ± 59.78 | 77.00 ± 21.26 | 0.679 |
| LDH, U/L | 211.08 ± 77.18 | 433.43 ± 574.54 | 0.000 |
| CRP, mg/L | 12.89 ± 24.69 | 58.84 ± 56.48 | 0.000 |
| ESR, mm/h | 38.51 ± 30.58 | 62.43 ± 34.03 | 0.001 |
|
Univariate analysis‡ Relative risk (95% CI) of poor outcome§ |
P-value | ||
| Age≥60 y | 3.6 (1.6–8.0) | 0.001 | |
| Diabetes | 5.9 (2.7–13.0) | 0.000 | |
| Other comorbid disease | 8.9 (3.0–26.0) | 0.000 | |
|
Multivariable analysis‡ Relative risk (95% CI) of poor outcome§ |
P-value | ||
| Age≥60 y | 1.9 (0.8–4.2) | 0.134 | |
| Diabetes | 3.0 (1.3–6.8) | 0.007 | |
| Other comorbid disease | 5.9 (1.9–17.8) | 0.002 | |
Data are median (IQR), n (%), or mean (SD).
APTT, Activated partial thromboplastin time; ALT, Alanine aminotransferase; AST, Aspartate aminotransferase; Scr, Serum creatinine; LDH, Lactate dehydrogenase; CRP, C-reaction protein; ESR, Erythrocyte sedimentation rate.
†
Defined as death or intensive care unit admission with or without mechanical ventilation.
‡
Results are from Cox proportional hazards model.
§
Reference group is younger than 60 years, with no diabetes, and no other comorbid disease (chronic pulmonary disease, cardiovascular disease, chronic renal diseases, cerebrovascular disease, liver disease, cancer, malnutrition, or autoimmune disease).