Table 4.
Mouse dosimetry of [177Lu]Lu-1C1m-Fc. These estimates come from mouse TIACs calculated from source organ time-activity curves
| Source organ | Mouse average organ mass (g) | Average TIAC (MBq·h/MBq) | Absorbed dose (mGy/MBq) |
|---|---|---|---|
| Tumor SK-N-AS | 0.16 | 3.91 | 1.82E+03 |
| Liver | 1.28 | 30.42 | 2.23E+03 |
| Kidneys | 0.33 | 2.04 | 7.05E+02 |
| Lung | 0.15 | 0.71 | 5.39E+02 |
| Spleen | 0.09 | 1.12 | 1.20E+03 |
| Heart | 0.20 | 0.33 | 3.63E+02 |
| Stomach | 0.10 | 0.55 | 1.15E+03 |
| Small intestine | 1.38 | 2.73 | 4.38E+02 |
| Colon | 0.87 | 1.74 | 3.28E+02 |
| Bladder | 0.10 | 0.13 | 3.16E+02 |
| Uterus* | 0.08 | 1.66 | 1.5 E+03 |
| Total body | 20.19 | 98.78 | 4.25E+02 |
*The uterus is not part of the source/target organ in the murine model of the OLINDA/EXM 2.1 software. Specific dosimetry was obtained with the sphere model of the OLINDA/EXM 2.1 where the organ-specific average mass and TIAC were applied