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. 2020 Aug 17;10:13899. doi: 10.1038/s41598-020-70969-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ubidecarenone induces G₂/M cell-cycle arrest of glioblastoma but not non-cancerous cell lines. (A) Cell cycle analysis and quantification of human U251 glioma cells treated with 0, 75, 115, 230, 345, or 460 µM ubidecarenone. The percentage of cells in each phase (G_0/1, S or G₂ + M) is estimated from the frequency histograms. The percentage of cells in G₂ + M phase is highlighted. (B) Quantification of human U251 glioma, rat C6 glioma, HA, or mouse NIH3T3 fibroblast cells in each cell phase. All data presented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 compared to control (no drug exposure) at the same cell cycle phase.