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. 2020 Aug 17;10:290. doi: 10.1038/s41398-020-00951-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Manhattan plot a and corresponding quantile-quantile plot b in GWAS for all male probands vs their unaffected brothers. We conducted a GWAS in the Simons Simplex Collection data set of 597 male probands and 370 unaffected brothers genotyped by the Illumina Human Omni2.5 array using the sib transmission/disequilibrium test (sib-TDT). We observed no significant associations in this GWAS with the genome-wide threshold of P = 5.0 × 10⁻⁸. The blue horizontal line indicates the genome-wide suggestive threshold of p = 1.0 × 10⁻⁵.