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. 2020 Aug 17;11(8):640. doi: 10.1038/s41419-020-02819-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Hierarchical clustering of genes that were significantly and differentially expressed in HT-29-shFXR cells and control cells. Data were log2 normalized. b Pathway analysis of genes that were significantly and differentially expressed in HT-29-shFXR cells and control cells using KEGG database. c The effect of FXR knockdown or overexpression on the luciferase activities of TOP/FOP-Flash reporter plasmid. d The effect of FXR knockdown or overexpression on the mRNA levels of cyclin D1 and c-Myc in colon cancer cells detected by real-time PCR. e, f The effect of FXR knockdown (e) or overexpression (f) on the protein levels of cyclin D1 and c-Myc in colon cancer cells detected by western blotting analysis. All data are the mean ± SD of three independent experiments. *P < 0.05.