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. 2020 Aug 17;10:13901. doi: 10.1038/s41598-020-70873-7

Table 2.

Adjusted odd ratios and 95% confidence intervals of gestational diabetes mellitus requiring insulin therapy by smoking status, amount and duration.

n (%) Events (n) Incidence ratea Model 1 Model 2
Smoking status
Nonsmoker 300,126 (92.3) 1,795 6.0 1 (ref.) 1 (ref.)
Former smoker 12,174 (3.7) 143 11.7 1.83 (1.54, 2.18) 1.55 (1.27, 1.90)
Current smoker 12,997 (4.0) 176 13.5 2.36 (2.01, 2.77) 1.73 (1.42, 2.09)
Amount of smoking (no. of cigarettes smoked per day)
Nonsmoker 300,126 (92.3) 1,795 6.0 1 (ref.) 1 (ref.)
Former smoker
 < 15 11,454 (3.5) 127 11.1 1.75 (1.46, 2.11) 1.49 (1.21, 1.84)
 ≥ 15 720 (0.2) 16 22.2 2.93 (1.77, 4.85) 2.42 (1.36, 4.31)
Current smoker
 < 15 11,736 (3.6) 150 12.8 2.26 (1.90, 2.68) 1.65 (1.35, 2.03)
 ≥ 15 1,261 (0.4) 26 20.6 3.27 (2.19, 4.88) 2.35 (1.46, 3.79)
Duration of smoking (years)
Nonsmoker 300,268 (92.3) 1,797 6.0 1 (ref.) 1 (ref.)
Former smoker
 < 5 4,816 (1.5) 50 10.4 1.93 (1.45, 2.56) 1.60 (1.14, 2.23)
 ≥ 5 7,265 (2.2) 92 12.7 1.78 (1.43, 2.21) 1.53 (1.20, 1.95)
Current smoker
 < 5 2,347 (0.7) 19 8.1 1.84 (1.16, 2.90) 1.38 (0.82, 2.30)
 ≥ 5 10,601 (3.3) 156 14.7 2.43 (2.05, 2.89) 1.78 (1.45, 2.19)
Amount × duration of smoking (pack-years)
Nonsmoker 300,126 (92.3) 1,795 6.0 1 (ref.) 1 (ref.)
≤ 2 13,625 (4.2) 139 10.2 1.86 (1.56, 2.21) 1.50 (1.22, 1.84)
2 <, ≤ 4 6,210 (1.9) 81 13.0 2.21 (1.76, 2.77) 1.71 (1.31, 2.22)
4 <, ≤ 6 3,222 (2.0) 49 15.2 2.23 (1.67, 2.98) 1.60 (1.13, 2.26)
6 <, ≤ 8 1,085 (0.3) 18 16.6 2.20 (1.37, 3.53) 1.97 (1.14, 3.40)
8 <, ≤ 10 568 (0.2) 16 28.2 2.97 (1.76, 5.00) 2.34 (1.22, 4.51)
> 10 461 (0.1) 16 34.7 3.27 (1.96, 5.45) 2.29 (1.25, 4.22)

Model 1: Adjusted for age, alcohol drinking, regular exercise, and income status.

Model 2: Adjusted for model 1 + body mass index, fasting blood glucose, family history of diabetes, and dyslipidemia.

aPer 1,000 person-years.