. 2020 Aug 11;11:484. doi: 10.3389/fendo.2020.00484

Table 3.

Histomorphometry of injured muscles in WT vs. 5LOKO mice.

Parameters	Groups/Periods	Y WT ♂	Y WT ♀	A WT ♂	A WT ♀	Y KO ♂	Y KO ♀	A KO ♂	A KO ♀
Muscle Inflam (%)	7 days	16 ± 5^a	14 ± 2^a	14 ± 5^a	15 ± 10^a	11 ± 3^a	13 ± 4^a	16 ± 4^a	14 ± 7^a
	14 days	14 ± 6^a^*	18 ± 9^a^*	43 ± 8^b^*^#	38 ± 7^b^*^#	10 ± 4^a^*	11 ± 5^a^*	25 ± 7^b^*^#	22 ± 4^b^*^#
CSA (μm²)	7 days	1,088 ± 661^a	977 ± 474^a	894 ± 515^a	955 ± 424^a	1,341 ± 715^a	1021 ± 516^a	994 ± 199^a	751 ± 290^a
	14 days	1,298 ± 724^a	1,127 ± 446^a^*	739 ± 94^a	505 ± 101^a^*	1,451 ± 432^a	1,361 ± 530^a	869 ± 383^a	741 ± 319^a
Centralized Myonuclei (%)	7 days	24 ± 18^a	26 ± 20^a	20 ± 11^a	19 ± 10^a	37 ± 13^a	34 ± 8^a	26 ± 4^a	24 ± 10^a
	14 days	23 ± 16^a	28 ± 17^a	21 ± 18^a	25 ± 11^a	39 ± 17^a	37 ± 14^a	29 ± 15^a	37 ± 12^b

Results are presented as the means (±SD) for each parameter.

In the comparison between lines, different letters (a vs. b) indicate significant difference for time points (7 vs. 14 days post-surgery) of the same group in each evaluated parameter (p < 0.05). In the comparison between columns, symbol

indicates comparison between columns: the effect of age (Y vs. A) in groups of same genotype and gender (e.g., Y ♀ WT vs. A ♀ WT); symbol

indicates the effect of different genotypes (WT vs. KO) in groups of same age and gender (e.g., Y ♀ WT vs. Y ♀ KO). Statistically significant differences are indicated between groups with equal symbols (p < 0.05). Y = 3 months; A = 18 months. No statistical significant differences were found between genders (♂ vs. ♀) in the comparison of the same genotype and age (e.g., Y ♀ WT vs. Y ♂ WT).