TABLE 1.

The predictive ability of synapse score adjusted using WHO grade, IDH mutation, and 1p/19q codeletion.

Datasets	Hazard ratio (95% CI) (no. of samples)
	Unadjusted	Grade-adjusted	IDH Status-adjusted	1p/19q Codeletion-adjusted
CGGA Microarray	0.0379 (0.0151–0.0947)*** (n = 298)	0.270 (0.0852–0.856)* (n = 295)	0.0645 (0.0249–0.167)*** (n = 296)	0.0491 (9.04 × 10–3 to 0.267)*** (n = 91)
CGGA RNAseq batch 1	5.77 × 10–5 (1.15 × 10–5 to 2.89 × 10–4)*** (n = 311)	1.04 × 10–3 (1.57 × 10–4 to 6.85 × 10–3)*** (n = 307)	2.97 × 10–5 (3.49 × 10–6 to 2.52 × 10–4)*** (n = 310)	2.93 × 10–4 (4.61 × 10–5 to 1.86 × 10–3)*** (n = 303)
CGGA RNAseq batch 2	3.31 × 10–4 (9.18 × 10–5 to 1.20 × 10–3)*** (n = 619)	9.17 × 10–3 (1.99 × 10–3 to 0.0423)*** (n = 619)	5.62 × 10–3 (1.16 × 10–3 to 0.0272)*** (n = 574)	7.85 × 10–4 (1.72 × 10–4 to 3.58 × 10–3)*** (n = 555)
TCGA GBM + LGG	2.84 × 10–7 (4.00 × 10–8 to 2.02 × 10–6)*** (n = 695)	8.18 × 10–3 (4.13 × 10–4 to 0.162)** (n = 634)	4.83 × 10–3 (2.96 × 10–4 to 0.0788)*** (n = 685)	9.48 × 10–7 (1.03 × 10–7 to 8.77 × 10–6)*** (n = 688)
GSE107850	1.53 × 10–4 (2.20 × 10–6 to 0.0107)*** (n = 195)		3.09 × 10–4 (3.03 × 10–6 to 0.0314)*** (n = 180)

Hazard ratio (HR) and 95% confidence interval (95% CI) of synapse score using univariate and multivariate Cox proportional hazards regression models for gliomas were shown. HR with 95% CI that does not include one is considered significant. *p < 0.05, **p < 0.01, ***p < 0.001.