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. 2020 Aug 11;14:139. doi: 10.3389/fnbeh.2020.00139

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Copyright © 2020 Jarrin, Pandit, Roche and Finn.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Effects of optogenetic stimulation (ChR2) or inhibition (ArchT) of glutamatergic neurons in the ACC on formalin-evoked nociceptive behavior of male Sprague-Dawley rats. Data are mean ± SEM (n = 8–10 per group). **p < 0.01, *p < 0.05 ChR2 vs control. (B) Effects of optogenetic stimulation (ChR2) or inhibition (ArchT) of glutamatergic neurons in the ACC on formalin-evoked nociceptive behavior of female Sprague-Dawley rats. Data are mean ± SEM (n = 7–11 per group). *p < 0.05 ChR2 vs control. ⁺p < 0.05 ChR2 female vs ChR2 male, and ^&p < 0.05 ArchT female vs ArchT male.