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. 2020 Aug 11;14:139. doi: 10.3389/fnbeh.2020.00139

FIGURE 4.

FIGURE 4

(A) Effects of optogenetic stimulation (ChR2) or inhibition (ArchT) of glutamatergic neurons in the ACC on formalin-induced conditioned place aversion (F-CPA) in combined male and female Sprague-Dawley rats. Data are mean ± SEM (n = 7–11 per group). **p < 0.01 vs control. (B) Effects of optogenetic stimulation (ChR2) or inhibition (ArchT) of glutamatergic neurons in the ACC on formalin-induced conditioned place aversion (F-CPA) in male Sprague-Dawley rats. Data are mean ± SEM (n = 8–10 per group). (C) Representative heat map images of post-conditioning trials for each treatment group in male rats. (D) Effects of optogenetic stimulation (ChR2) or inhibition (ArchT) of glutamatergic neurons in the ACC on formalin-induced conditioned place aversion (F-CPA) score of female Sprague-Dawley rats. Data are mean ± SEM (n = 7–11 per group). (E) Representative heat map images of post-conditioning trials for each treatment group in female rats.