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. 2020 Aug 11;8:704. doi: 10.3389/fcell.2020.00704

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Copyright © 2020 Dong, Yang, Ju, Zhu, Wang, Zou, Sun and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fufang Yiliu Yin (FYY) modulated the expression of the PI3K/Akt signaling pathway and BCL-2 family proteins. Relative PI3K mRNA expression was altered by FYY treatment in HCT116 and SW480 cells (A) (n = 3 per group). Expression levels of PI3K, AKT, p-AKT, BCL-2, BCL-XL, and BAX were altered by FYY treatment in HCT116 (B) and SW480 cells (C) (n = 3 per group). Values are shown as the mean ± SD, *p < 0.05, **p < 0.01, and ***p < 0.001 vs. control group. The p-values were obtained using ANOVA.