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. 2020 Aug 11;8:704. doi: 10.3389/fcell.2020.00704

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Copyright © 2020 Dong, Yang, Ju, Zhu, Wang, Zou, Sun and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fufang Yiliu Yin (FYY) inhibited tumor growth in vivo. (A) Subcutaneous xenograft tumors after 36 days demonstrated that FYY inhibited xenograft tumor growth (n = 5 per group). (B) Tumor volume was significantly smaller after 14 days of FYY treatment (n = 5 per group). IHC analysis of Ki-67 expression in FYY-treated tumor and liver tissues (×400 magnification). The p-values were obtained using ANOVA. (C) Protein expression levels of PI3K, AKT, p-AKT, BCL-2, BCL-XL, and BAX in tumor tissues (n = 3 per group). Values are shown as the mean ± SD, *p < 0.05 and **p < 0.01 vs. control group. The p-values were obtained using Student’s t-test.