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. 2020 Aug 11;8:943. doi: 10.3389/fbioe.2020.00943

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Copyright © 2020 Yaman, Ramachandramoorthy, Oter, Zhukova, Nguyen, Sabnani, Weidanz and Nguyen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characterization of T-MNPs. (A) TEM images of T-MNPs at 1:2 NP to membrane protein weight ratio. (B) Size, polydispersity and zeta potential of PLGA NPs and T-MNPs analyzed using Dynamic Light Scattering (DLS). (C) Stability of T-MNPs in 0.9% saline (at varying NP to membrane protein weight ratios: 1:0.5, 1:1, 1:2, and 1:3) evaluated by change in NPs size over a 2-day period using DLS. (D) Cumulative% drug release from T-MNPs (varying NP to membrane protein ratios of 1:0.5, 1:1, 1:2 versus PLGA NPs) performed in phosphate buffered saline over 28 days. Samples were analyzed using UV-vis spectrophotometer.