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Schematic showing some miRNAs involved in human OA synovial pathology. MiR-381a-3p, miR-34a, miR-146a, and miR-181a promote inflammatory mechanisms (32, 33). MiR-26a-5p, miR-146a, miR-122, and miR-181c suppress the expression of inflammatory cytokines (24, 26, 27, 31). MiR-181c and miR-770 suppress fibroblast-like synoviocyte proliferation (24, 25). MiR-29a and miR-338-3p exhibit anti-fibrotic effects (34, 35).
