Table 1.
Latency to onset of seizure (score 7-8) on vitexin treatments.
| Convulsant Agent | Latency to onset of seizure (seconds) | |||||
|---|---|---|---|---|---|---|
| Ctrl | VEH | DZP (2 mg/kg) | Vitexin (1.25 mg/kg) | Vitexin (2.5 mg/kg) | Vitexin (5 mg/kg) | |
| NMDA (150 mg/kg) | 4409.50 ± 92.48 | 4326.30 ± 43.49 | NS | 4403.83 ± 98.63 | 4514.50 ± 63.59 | 4548.50 ± 70.52 |
| Kainic acid (30 mg/kg) | 4491.33 ± 77.88 | 4546.33 ± 77.52 | NS | 4693.0 ± 74.59 | 4404.83 ± 116.83 | 4468.72 ± 124.72 |
| PTZ (90 mg/kg) |
77.4 ± 14.63 | 78.00 ± 7.38 | NS | 53.66 ± 9.07# | 141.2 ± 29.08*# | *# NS |
| Picrotoxin (6 mg/kg) | 1101.0 ± 47.29 | 1103.66 ± 47.99 | NS | 745.8 ± 65.35*# | 1396.6 ± 43.14*# | *# NS |
∗p < 0.05 versus control group (Ctrl – Saline Control) and #p < 0.05 between different doses of vitexin. One-way ANOVA; Tukey post hoc test. NS, no seizure.