Table 2.
Genotype and allelic frequencies of COL4A4 rs2228557 and TIMP-1 rs4898 polymorphisms between keratoconus (KC) patients and healthy controls.
|
| ||||
| Variants | KC Patients n (%) | Controls n (%) | *OR (95% CI) | P -value |
| rs2228557,COL4A4 | ||||
| CC | 67 (47.8) | 61 (40.7) | Ref. | — |
| CT | 39 (27.9) | 37 (24.7) | 0.96 (0.54–1.69) | 0.887 |
| TT | 34 (24.3) | 52 (34.6) | 0.59 (0.34–1.03) | 0.067 |
| Allele | ||||
| C | 173 (61.8) | 159 (53) | Ref. | — |
| T | 107 (38.2) | 141 (47) | 0.69 (0.50–0.97) | 0.035 |
| rs4898,TIMP-1 | Male | Male | ||
| CY | 46 (75.4) | 37 (57) | Ref. | — |
| TY | 15 (24.6) | 28 (43) | 0.43 (0.20–0.92) | 0.038 |
| Female | Female | |||
| CC | 28 (47.5) | 31 (52.5) | Ref. | — |
| CT | 29 (49.2) | 30 (50.8) | 1.01 (0.46–2.19) | 0.97 |
| TT | 22 (47.8) | 24 (52.2) | 1.07 (0.52–2.20) | 0.854 |
| Allele | ||||
| C | 85 (53.8) | 92 (54.1) | Ref. | — |
| T | 73 (46.2) | 78 (45.9) | 1.01 (0.66–1.56) | 0.953 |
| Ref., reference; OR, odds ratio; CI, confidence interval; n, number *Adjusted for sex and age. (Y states for the Y-chromosome) | ||||