Table 1.

Frequency of SD-OCT morphologic changes of herpetic stromal keratitis according to inflammatory status and type of keratitis.

Corneal structure change (cross-sectional analysis)	Active HSK No. Eyes (%) (n = 24)	Inactive HSK No. Eyes (%) (n = 29)	P -value	Non-necrotizing keratitis No. Eyes (%) (n = 44)	Necrotizing keratitis No. Eyes (%) (n = 9)	P -value
Epithelial remodeling	1 (4.1)	21 (72.4)	$<$ 0.001*	19 (43.1)	3 (33.3)	0.02*
Epithelial thickening	16 (66.6)	1 (3.4)	$<$ 0.001*	13 (29.5)	4 (44.4)	0.387
Epithelial damage (ulceration)	5 (20.8)	0 (0.0)	$<$ 0.001*	0 (0.0)	5 (55.5)	$<$ 0.001*
Stromal thinning ($<$ 450 µm)	6 (25.0)	20 (68.9)	0.004*	20 (45.4)	7 (77.7)	0.080
Stromal edema ($>$ 570 µm)	19 (79.1)	1 (3.4)	$<$ 0.001*	15 (34.0)	4 (44.4)	0.652
Stromal inflammatory infiltration	19 (79.1)	2 (6.8)	$<$ 0.001*	14 (31.8)	7 (77.7)	0.011*
Stromal scarring ($>$ 35% surface)	15 (62.5)	26 (89.6)	0.042*	34 (77.2)	9 (100.0)	0.095
SD-OCT, spectral-domain optical coherence tomography; HSK, herpetic stromal keratitis ${}^{*}$ P-value $<$ 0.05 was considered as statistically significant (Mann–Whitney U-test for two independent samples).